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Human htr2a genome location and htr2a gene details page in the ucsc genome browser Biased expression in brain (rpkm 11.8) and gall bladder (rpkm 0.8). Overview of all the structural information available in the pdb for uniprot

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Function, proteins, disorders, pathways, orthologs, and expression. Protein coding 关于 htr2a cytogenetic location 最近的发现表明，即使位于正位结合位点之外的HTR2A SNPs也是体外迷幻药物药理学的驱动因素。 重要的是，5-HT2R系统在配体-受体相互作用中的这种分子信号多样性，未来可能在治疗药物的设计中发挥概念性作用。

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Human ortholog (s) of this gene implicated in several diseases, including alcohol use disorder

[provided by alliance of genome resources, apr 2022] HTR2A的作用机制主要是通过与5-羟色胺（5-HT）等配体结合，激活G蛋白，进而调节下游效应子的活性，如腺苷酸环化酶，影响细胞内的信号传递。 HTR2A参与调节多种生理功能，包括情绪、认知、疼痛感知、血管收缩等。 本文详细介绍了HTR2A基因的功能、作用机制、信号通路及其与多种疾病的关系。 HTR2A编码的5-HT2A受体是G蛋白偶联受体家族的一员，主要参与神经递质5-羟色胺的信号传导，对情绪、认知、睡眠等多种生理功能有重要影响。 外部链接 醫學主題詞表（MeSH）： 5-HT 2A +Receptor Human HTR2A genome location and HTR2A gene details page in the UCSC Genome Browser （英语：UCSC Genome Browser） . PDB 中 UniProt 可用的所有結構信息之概述： P28223 (5-hydroxytryptamine receptor 2A) 在 PDBe-KB （英语：PDBe-KB） 。

5-HT2A靶点全称：5-hydroxytryptamine receptor 2A 又名HTR2A , 5-HT2A, HTR2, 5-羟色胺受体2A，5-HT2A 受体是广泛分布于全身的 G 蛋白偶联受体，据研究发现抑郁症患者比正常人拥有更多的 5-HT2A受体，这也表明该类疾病发病机制与5-HT2A受体数量增多有直接的关联， Find diseases associated with this biological target and compounds tested against it in bioassay experiments.